CBD

Possible side effects of CBD

Side effects of CBD

CBD is a herbal remedy made from a plant - in this case, the cannabis sativa plant. Cannabis sativa has been used for its healing and mind altering properties for thousands of years. 

There are two types of cannabis sativa: hemp and marijuana. The hemp plant is the source of the CBD used in most products. 

What is CBD?

CBD belongs to a group of substances called cannabinoids that come from the cannabis sativa plant. In fact, there are dozens of cannabinoids as well as other substances in cannabis sativa.  

CBD is the main cannabinoid in hemp. It has various healing properties. For example, it appears to reduce inflammation, the body's response to illness or injury. In this way, it can be helpful in treating many different diseases. CBD is not psychoactive: it has no mind-altering effects.  

CBD vs. THC 

To better understand CBD, it is helpful to compare it to tetrahydrocannabinol (THC). Many people are familiar with THC. It is the most famous of the cannabinoids. THC was discovered long before CBD. THC is the substance in marijuana that causes the high.  

CBD comes from the hemp plant and its main property is healing. THC is the main cannabinoid in the marijuana plant. It has a mind altering effect. Marijuana contains more THC than CBD. Hemp is very low in THC, less than 0,2 percent, and not enough to be high. As of 2018, CBD made from hemp has been legal in the United States. 

How does CBD work?  

How the CBD flowers / buds - and the systems it affects in the body - is complex and is still being explored. As mentioned earlier, CBD belongs to a class of chemicals called cannabinoids.

Because it comes from a plant, it's called a phytocannabinoid. The body also produces natural cannabinoids called endocannabinoids. Cannabinoids act on cannabinoid receptors.  

Cannabinoid receptors are part of the complex endocannabinoid system (ECS). It regulates the release of neurotransmitters (chemicals that communicate between nerve cells) in the brain and other parts of the nervous system.

The ECS reacts to both types of cannabinoids, phyto- and endo-cannabinoids. By acting on the ECS, CBD can have many different effects on the body. Examples of this are: balancing the general body functions (homeostasis), reducing the sensation of pain and weakening the body's reaction to injuries or infections (inflammation). 

What medical uses are there for CBD? 

CBD is recommended for many different purposes, some verified and some not. The prescription drug Epidiolex is approved for the treatment of two rare seizure disorders.  

Studies are still ongoing, but there is evidence that CBD may be useful in relieving anxiety, chronic (long-term) pain how back pain and insomnia or sleep disorders could be effective. 

There are also Oral, topical and inhalation studies CBD for many other conditions including: dystonia (movement disorders), fragile X syndrome (rare genetic disorder), graft-versus-host disease (bone marrow transplant rejection), multiple sclerosis (MS), opioid withdrawal, schizophrenia, and smoking cessation .

CBD is also used for the relief of Parkinson's symptoms, however there are some studies that advise against it. Have you tried CBD yet? There are many other ways you can get back pain relief or insomnia relief without ingesting it. Check out some of the other methods Goodpath's integrative medicine approach is using to relieve your symptoms here:

Types of CBD 

There are two ways of taking CBD (orally) or applying it to the skin (topical). CBD Oil can be used in both ways. Other oral forms of CBD include edible gummy bears and capsules. Topical CBD can also be used as a lotion, cream, or balm. 

CBD dosage 

The dosage of CBD for various medical conditions is still being researched. CBD should be used according to the manufacturer's instructions. Read the label carefully and follow it.

Do not use more than prescribed. A higher dosage can increase the risk of side effects or cause other problems. The dose of CBD also depends on the shape and strength and whether or not it contains other active ingredients.  

What are the side effects of CBD? 

The most common side effects are tiredness or drowsiness and diarrhea. Other side effects are: dry mouth, vomiting, decreased appetite, weight loss and increased liver values ​​in blood tests. If taken by mouth: CBD may be safe in reasonable doses.

Doses up to 200 mg daily have been used safely for up to 13 weeks. A special prescription CBD product (Epidiolex) was used in higher doses under the guidance of a health care provider. 

Signs of liver damage have also been reported at high doses of the prescription CBD supplement (Epidiolex). When used on the skin: There is not enough reliable information to know whether CBD is safe or what side effects it could have. 

Many studies on CBD, including the side effects, are still in the early stages. Most people tolerate CBD well. Since CBD can cause drowsiness or drowsiness, great caution should be exercised when driving a car, using tools or other devices, or engaging in other risky activities. 

interactions 

CBD and medical conditions 

CBD should not be used by people with liver disease or Parkinson's disease. 

CBD and medication 

CAUTION: CBD should not be taken with medication prescribed to control seizures. There are many other drugs that should not be taken with CBD.

Taking CBD can increase the effects of these drugs. For example, taking CBD along with medications that cause drowsiness can make the person even more drowsy. 

CBD can also increase the risk of side effects from certain drugs when taken with them. Talk to your doctor or pharmacist before taking CBD with other medications.  

CBD, foods and herbs 

Fatty foods can increase the body's absorption of CBD. Taking CBD with other herbs that cause drowsiness can increase this effect. 

Medical research 

Does Oral CBD Help With Pain? Research on the safety and effectiveness of oral CBD for pain is ongoing. Some of the research includes: The National Academies of Sciences (NAS) found significant evidence that cannabis is an effective treatment for long-term (chronic) pain.

Much of the research, however, has been carried out outside of the United States, and the forms of cannabis studied in the United States did not match those that are commonly used. Reviews and meta-analyzes of cannabinoids found the following: In the Studies looked at the use of cannabinoids (THC alone and CBD in combination with THC) in people with chronic pain. In general, there were improvements in pain measurement, but these were not statistically significant. 

The studies provided evidence, albeit not of high quality, that cannabis-based drugs relieve long-term nerve pain (chronic neuropathic pain). A plant-based THC / CBD oral spray was used in all but two studies (the other two used synthetic THC orally). 

Observational studies and randomized controlled trials (RCTs) of the effectiveness of cannabinoids for chronic pain not related to cancer, one in three cannabinoid users found a pain reduction of 30%. This was considered significant. 

Does Topical CBD Help With Pain? 

There is also ongoing research into the safety and effectiveness of CBD for topical use. Research findings include the following: In one Animal study Transdermal CBD has been found to reduce the pain and inflammation associated with arthritis. 

Topical cannabidiol oil was studied in 29 people with peripheral lower limb neuropathy. After using the oil for four weeks, participants had less severe and stabbing pain and fewer other uncomfortable sensations. 

The use of transdermal cannabidiol has been studied in people with TMD (TMD) that caused myofascial (muscle-enveloping) pain. Study participants experienced less muscle activity and pain after applying the topical CBD for 2 weeks. 

Does Oral CBD Help You Sleep? 

Orally ingested CBD can help with sleep. Research findings include the following: Early research suggests that 160 mg of cannabidiol at bedtime significantly improves sleep time in patients with insomnia compared to a placebo. Smaller doses did not have this effect.

In addition, the patients did not feel sleepy the next morning. Initial research on CBD for treating insomnia suggests that it could be effective. More studies are needed.

Animal studies with CBD found that the total length of sleep increased and the quality of sleep improved when sleep problems were linked to anxiety. Medical cannabis users reported using cannabis with higher levels of CBD and lower levels of THC to treat their insomnia. They also reported a decrease in the time it took to fall asleep. A review and meta-analysis of 8 studies with poor evidence on cannabis-based drugs found that they were better at reducing sleep problems when compared to inactive drugs (placebo). A review of clinical studies on the effects of cannabinoids on sleep found that cannabinoids can improve sleep quality, reduce insomnia, and reduce the time it takes to fall asleep.

However, there were many limiting factors such as: B. the small number of people examined and the evaluation of sleep in the context of studies on other diseases. An app was used to measure changes in insomnia in over 400 people who took medical cannabis. The mean symptom severity decreased 4,5 points on a 10-point scale, meaning a significant improvement in insomnia. 

In another Review article with meta-analysis of 104 studies Cannabinoids were studied for the treatment of chronic pain without cancer. This review and analysis also looked at the effects of cannabinoids on sleep. The evidence of improved sleep was poor. 

Conclusion 

The bottom line on CBD is that the initial research is promising, but there is still a lot to learn. It can help with some medical conditions such as long-term pain and sleep. Because it is so widely used and recommended for so many problems, it must be used carefully and obtained from reliable sources. CBD is just one of many supplements that can help relieve back pain or insomnia.

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